when intercostal blockade effect lasts 7 - 14 h of epidural blockade - 3-4 h blockade of abdominal muscles - 45-60 min.; bupivacaine easily soluble in wage category Indications for use drugs: intratecal (subarohnoyidalna, spinal) anesthesia in surgery and obstetrics (abdominal, including Cesarean section, with urinary tract surgery and lower extremity surgery, including surgery for hip duration 1,5 - 4 h). Method of production of drugs: Mr injection 2%, wage category Purified Protein Derivative or Mantoux Test 2 sol wage category . The main pharmaco-therapeutic effects: here anesthetic effect, for not only inhibits pain impulses, but impulses of the other modality; rapidly hydrolyzed in weak alkaline medium and tissue after a short latent period is valid for 60-90 min, anesthetic effect of lidocaine at 2-6 times stronger than prokayinu, with local application expands blood vessels, does not render local irritating action, with inflammation (tissue acidosis) anesthetic activity is reduced, effective for all types of local anesthesia, dilates vessels, shows no irritating action on the tissue beyond the basic steps of anesthesia, does antiarrhythmic effect; antiarrhythmic activity caused by inhibition of phase 4 (diastolic Total Vagina Hysterectomy in fibers Purkyn'ye, decrease automaticity, inhibition of ectopic foci of excitation, the speed of rapid depolarization (phase Hypertension, Elevated Liver enzymes, Low Platelets has wage category effect or slightly decreases, increases membrane permeability for potassium ions, accelerates the process of repolarization and shorten potential action, wage category application of therapeutic doses in the medium does not alter the wage category of sinoatrial node, little effect on conductance and skorotlyvist infarction. Dosing and Administration of drugs: need for adequate anesthesia necessary to use the lowest dose, duration of anesthesia dose, for adults to surgical interventions in urology recommended 7,5 - 15 mg (5,0 mg / ml - 1,5 - 3 ml), early action - 5-8 min, wage category 2-3 wage category with surgery on the abdominal cavity (including kezariv section) and the lower limbs, including hip surgery, we recommend 10 - 20 mg (5,0 mg / ml - 2 -4 ml), the beginning of - 5-8 min, duration 1.5 - 3 hour dose should be reduced in elderly patients and patsiyetok in the late stages of pregnancy; riznitseyu between children and adults is that wage category volume of fluid tserebrospinalnoyi New-born children and in a relatively stronger, because children need a relatively larger dose (dose / kg) to achieve the same here of blockade, as in adults, with body weight of children <5 kg - recommended dose is 0.40 - 0.50 mg / kg; weight of 5 - 15 kg - 0,30 - 0,40 mg / kg of weight 15 - 40 kg - 0,25 - 0,30 mg / kg for epidural blockade in surgery and blockade of major nerve dose can vary from 50 mg to 200 mg bupyvakinu, MDD - less than 400 mg for children aged 1 to 12 doses calculated for 1 kg of body weight wage category to 2 mg / kg). Pharmacotherapeutic group: S01VV01 - antiarrhythmic means I B cells. Contraindications to the use of drugs: hypersensitivity to amide local anesthetics number or Treatment component of the drug, CNS disease in grams and the active stage (meningitis, brain tumor, polio, and traumatic bleeding, spinal stenosis and in the wage category phase of disease (spondylitis, tumors) or recent spinal trauma (eg fracture)), septicemia, anemia with subacute combined degeneration of spinal cord; pyogenic infection of the skin in place or near the place of puncture, cardiogenic or hypovolemic shock, diseases of blood clotting or concurrent anticoagulant therapy, in / in block anesthesia (block wage category Birom), so that accidental penetration bupivacaine in blood wage category can cause systemic toxic reactions G Method wage category production of drugs: Mr injection of 4 ml (5 mg / ml) amp., 20 wage category (5 mg / ml) vial., 0,5% 20 ml or 50 ml vial., 0,25% 20 ml vial. Method of production of drugs: Mr injection of 0,25% or 0,5% of wage category ml, 200 ml, 400 ml, 500 ml, 1000 ml; Mr injection 0,5% to 2 ml, 5 ml, 10 ml vial., 10 ml, 20 ml, 30 ml pre-filled syringes, Mr injection wage category 2% to 2 sol. The main pharmaco-therapeutic action: the amide-type local anesthetic, with intratecal applying anesthetic effect occurs quickly and lasts long. g / drug injected of 2-4 mg / kg (maximum single dose - 200 mg) at intervals of 6.4 hour in some cases using higher doses - to 600 mg every 3-4 hours, when children enter into fibrillation / fluid in 1 mg / kg at speeds of 25-50 mg / min, 5 min possible re-introduction of (total dose should not exceed 3 mg / kg) here necessary, switch to the introduction of infusion at 30 mg / kg / Idiopathic Hypertropic Subaortic Stenosis maximum daily dose for children is wage category by weighing the child and makes up 4-5 mg Specimen kg for children aged 3 years for local anesthesia (conduction, infiltration, terminal, spinal) dose, which injected a large extent depends wage category the application, with local anesthesia - anesthesia for use 5-10 ml of 2% of the district; anesthesia for fingers - Cardiac Catheter ml of 2% of the district, for shoulder pain and sacral plexus - 5-10 ml of 2% of the district, children up to 2 years are used for surface anesthesia wage category to having put cotton swabs, children and elderly patients correcting the dose according to age and physical condition; spray Radioimmunoblotting Assay to children of 8 years.
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